Biotechnology & nanotechnology
fatemeh karimiyan; mahboobeh madani; noshin naghsh
Volume 28, Issue 4 , September and October 2021, , Pages 545-555
Abstract
Introduction: Today, carotenoids draw attention because of their antioxidant and antitumor properties and also usage as natural food colors. In this study, the biotechnological production of carotenoid by the yeast Rhodoturola musilaginosa and its effect on the lipid profile of male mouse were investigated.
Materials ...
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Introduction: Today, carotenoids draw attention because of their antioxidant and antitumor properties and also usage as natural food colors. In this study, the biotechnological production of carotenoid by the yeast Rhodoturola musilaginosa and its effect on the lipid profile of male mouse were investigated.
Materials and Methods: In this semi-experimental study, carotenoids were extracted from R. mucilaginosa using the Davis method. Twenty four male mice were randomly divided into four groups of six each. Two treatment groups received 16 and 32 mg/kg carotenoid peritoneally. One group received 400 mg/kg R. mucilaginosa powder by gavage. Control group received 0.5 ml physiological serum intraperitoneally. Blood samples were then collected and lipid profile was studied for triglyceride, cholesterol, LDL and HDL. The results were analyzed by SPSS 21 and comparisons were conducted using one-way ANOVA and Kruskal-Wallis test.
Results: The lowest serum concentrations of triglyceride and VLDL were observed in the group given 32 mg/kg carotenoid compared to the gavage and control groups. Mean serum cholesterol and HDL concentrations in the groups were not significantly different. The highest mean LDL concentration was observed in the gavage group.
Conclusion: According to the results of this study, R. muscilaginosa carotenoid decreased serum concentrations of triglyceride, VLDL and cholesterol. Therefore, it seems that the possibility of using it as a dietary supplement be helpful.
Microbiology
maryam alsadat zarei; Mahboubeh Madani
Volume 25, Issue 1 , May and June 2018, , Pages 151-160
Abstract
Background: Teucrium polium is a medicinal plant which species have been used for over 2000 years in traditional medicine. The aim of this study was evaluation of the effect of ethanolic extract of Teucrium polium on Candida glabrata colonization in mice tissue. Material and Method: The study was performed ...
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Background: Teucrium polium is a medicinal plant which species have been used for over 2000 years in traditional medicine. The aim of this study was evaluation of the effect of ethanolic extract of Teucrium polium on Candida glabrata colonization in mice tissue. Material and Method: The study was performed on 90 mature male mices (9 per group), that were devided into 10 groups: normal, placebo, 3 treatment group (candida- extract), control positive (Candida glabrata) and control negative (extract). Treatment groups were received 50,100 and 200 mg/kg dosages of extract for 20 days (every other day) by intraperitoneal injection. At the end of injections, homogenized liver, spleen and kidney were cultured on SDA medium and then colony count were performed. Results: The results showed, that liver in 100 mg/kg, spleen and kidney in 200mg/kg haven’t any yeast. Discussion and Conclusion: According to the results, Teucrium polium extract, perhaps can stimulat the immunity against Candida glabrata. Keywords: Teucrium polium, Candida glabrata, liver, spleen, kidney